Interactions between apolipoprotein E, sex, and amyloid‐beta on cerebrospinal fluid p‐tau levels in the European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study (EPAD LCS)

Background Alzheimer’s Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE) ε4 allele strongest genetic risk factor for late-onset AD and associated with aberrant cerebrospinal fluid levels (CSF) total tau (t-tau), phosphorylated (p-tau), amyloid-β (Aβ). There some evidence that sex may mediate relationship between APOE status CSF tau, however, mixed. Method We aimed to examine association sex, status, Aβ on t-tau p-tau 1776 mid-to-late life individuals without a diagnosis dementia European Prevention Dementia (EPAD) longitudinal cohort study. Result found significant interaction levels. Specifically, was stronger male carriers relative female carriers. Further, females high (reflecting less cortical deposition), had significantly elevated non-carriers. However, there were no differences non-carriers Aβ. Conclusion An p-tau. These data suggest accumulation be independent females, but not males. Future work would benefit from replication separate cohorts, examination, consideration role hormones markers.